General Cell Based Assays
Eurofins Discoverx PathHunter eXpress MCHR1 U2OS β-Arrestin GPCR Assay, 10-Plate Kit. (93-0940E3CP5L)
The PathHunter MCHR1 eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. MCH) based activation of MCHR1 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged MCHR1 and EA-tagged β-Arrestin-2. Activation of MCHR1 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter Mouse Insulin Receptor B (INSRb) Functional Kinase Cell-Based Assay Kit (U2OS)
The PathHunter Mouse Insulin Receptor B (INSRb) Stable Cell Line Functional Kinase Assay (U2OS) measures INSRb receptor tyrosine kinase activity via ligand-induced SH2 domain protein recruitment. This is a complete kit that includes the cell vials and all required reagents needed for cell culture and running the assay.
Electron Microscopy Sciences Flim Sleeve 135 mm/20 exp with Frosted Open Flap
Polyguard Polypropylene film sleeves are the finest archival quality material, and are guaranteed to give you ultimate protection for your most important film negatives. Polyguard is 100% acid free, as well as being free from optical distortion. It is resistant to water, grease, oil, alkalies, and organic solvents. Polyguard is durable, yet pliable and gentle to the film and will not become brittle, crack, or abrade the film.
Type: Frosted Open Flap
Eurofins Discoverx PathHunter eXpress MRGPRE CHO-K1 β-Arrestin Orphan GPCR Assay, 10-Plate Kit. (93-0438E2ACP1L)
The PathHunter MRGPRE eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand based activation of MRGPRE GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged MRGPRE and EA-tagged β-Arrestin-2. Activation of MRGPRE stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. This is an orphan receptor without a known ligand. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter eXpress CXCR1 (IL8RA) U2OS β-Arrestin GPCR Assay, 10-Plate Kit. (93-0226E3CP0L)
The PathHunter CXCR1 (IL8RA) eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. CXCL8/IL8) based activation of CXCR1 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged CXCR1 and EA-tagged β-Arrestin-2. Activation of CXCR1 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Abcam LDL Uptake Assay Kit (Cell-Based)
LDL Uptake Assay Kit (Cell-Based)
The product is subject to the following: Abcam Restricted Use Statement
Eurofins Discoverx PathHunter Human PTGER4 β-Arrestin Cell-Based Assay Kit (U2OS)
The PathHunter Human PTGER4 β-Arrestin Stable Cell Line Assay (U2OS) contains a stable clonal cell line used to measure PTGER4 (GPCR) activity via recruitment of β-Arrestin2. This is a complete kit that includes the cell vials and all required reagents needed for cell culture and running the assay.
Eurofins Discoverx PathHunter Human Heregulin beta 1 (ErbB4) Functional Kinase Cell-Based Assay Kit (U2OS)
The PathHunter Human Heregulin beta 1 (ErbB4) Stable Cell Line Functional Kinase Assay (U2OS) measures ErbB4 receptor tyrosine kinase activity via ligand-induced SH2 domain protein recruitment. This is a complete kit that includes the cell vials and all required reagents needed for cell culture and running the assay.
Eurofins Discoverx cAMP Hunter eXpress CNR2 CHO-K1 GPCR Assay, 10-Plate Kit. (95-0183E2CP2L)
The cAMP Hunter CNR2 eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. CP 55,940) based activation of CNR2 GPCR activity via detection of decreasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type CNR2, a naturally Gi/Go coupled GPCR. Upon activation of CNR2, the decrease in levels of intracellular cAMP leads to a decreased signal from EFC when the cAMP detection kit is applied. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter eXpress LGR4 CHO-K1 β-Arrestin Orphan GPCR Assay, 10-Plate Kit. (93-0516E2ACP1L)
The PathHunter LGR4 (GPR48) eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand based activation of LGR4 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged LGR4 and EA-tagged β-Arrestin-2. Activation of LGR4 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. This is an orphan receptor without a known ligand. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter eXpress KDR Activity Assay, 10-Plate Kit. (93-0903E3CP16L)
The PathHunter KDR Activity eXpress kit provides an easy-to-use cell based assay to study small molecule drug candidates targeting RTKs. This kit assesses RTK activation via detection of resulting KDR phosphorylation-induced SH2 domain protein recruitment. This product uses EFC technology. The cell line overexpresses ProLink-tagged fusion of the KDR kinase domain with transmembrane and extracellular ligand binding domain of EGFR; and also an EA-tagged SH2 domain protein. Upon ligand induced receptor activation, cross-phosphorylation of the receptor leads to SH2-EA recruitment and production of EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter eXpress mPTGER4 DLD1 β-Arrestin GPCR Assay, 2-Plate Kit. (93-0982E13MCP25M)
The PathHunter mPTGER4 eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. prostaglandin E2) based activation of mPTGER4 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged mPTGER4 and EA-tagged β-Arrestin-2. Activation of mPTGER4 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. Please note that this product expresses the Mouse version of this protein. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx cAMP Hunter eXpress PTGER3 CHO-K1 GPCR Assay, 10-Plate Kit. (95-0159E2CP2L)
The cAMP Hunter PTGER3 eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. prostaglandin E2, cloprostenol) based activation of PTGER3 GPCR activity via detection of decreasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type PTGER3, a naturally Gi/Go coupled GPCR. Upon activation of PTGER3, the decrease in levels of intracellular cAMP leads to a decreased signal from EFC when the cAMP detection kit is applied. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Meso Scale Discovery R-PLEX Human C1q receptor ASY
The Meso Scale Discovery R-PLEX Human C1q Receptor Assay is a multiplex immunoassay panel that measures C1q Receptor in human serum plasma and cell culture supernatants This assay uses electrochemiluminescence (ECL) detection technology and provides high sensitivity up to 5-logs of dynamic range and low sample volume requirements The assay is available as a singleplex or as a multiplex combining up to 10 biomarkers per well It requires 50 L of sample and can perform up to 80 tests across two plates The assay takes 3 5 hours to complete and has a typical sensitivity of 19 pg/mL